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KMID : 0357319940290050477
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Journal of the Korean Society for Microbiology
1994 Volume.29 No. 5 p.477 ~ p.487
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A Role of Candida Albicans Proteinase in the Pathogenicity of Cnadida Infections
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Abstract
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We have studied the relationships between virulence for mice and an ability of proteinase production of Candida albicans. We have used two C. albicans strains with different proteinase activity, NIH A-207, which secretes proteinase, and NUM 678,
a
proteinase-deficient mutant strain. The mortality rates for mice infected with NIH A-207. were significantly higher than those infected with NUM 678(100% vs 20%). Mice immunized with purified NIH A-207 proteinase were found to be tolerant to the
infection with NIH A-207 Furthermore, injection of monoclonal antibodies against the proteinase into mice decreased the number of colony-forming units(CFU) recovered from kidneys of mice infected with NIH A-207. Protection from the infection
could
also
be achieved by the transfer of lymph node T cells from mice immunized with proteinase. These data clearly indicate that proteinase is a major virulent factor in C. albicans infection and suggest that both humoral and cellular immunity are
involved
in
the infection.
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KEYWORD
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